Neurotrophin Regulation of Gene Expression
نویسندگان
چکیده
منابع مشابه
Neurotrophin regulation of gene expression.
The neurotrophins comprise a family of secreted proteins that elicit profound responses in cells of the developing and mature vertebrate nervous system including the regulation of neuronal survival and differentiation. The molecular mechanisms by which the neurotrophins exert their effects have been the subject of intense investigation. The neurotrophins elicit responses in neurons via members ...
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Sensory neurons in the dorsal root ganglion (DRG) specifically project axons to central and peripheral targets according to their sensory modality. However, the molecular mechanisms that govern sensory neuron differentiation and the axonal projections remain unclear. The Runt-related transcription factors, Runx1 and Runx3, are expressed in DRG neuronal subpopulations, suggesting that they might...
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For all living cells, regulation of gene expression by extracellular signals is a fundamental mechanism of development, homeostasis, and adaptation to the environment. Indeed, the ultimate step in many signal transduction pathways is the modification of transcription factors that can alter the expression of specific genes. Thus, neurotransmitters, growth factors, and drugs are all capable of al...
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ژورنال
عنوان ژورنال: Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques
سال: 1997
ISSN: 0317-1671,2057-0155
DOI: 10.1017/s0317167100032935